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Some lymphocytes migrate to the thymus, where they mature into T cells; others remain in the bone marrow, where—in humans—they develop into B cells. Most lymphocytes are short-lived, with an average life span of a week to a few months, but a few live for years, providing a pool of long-lived T and B cells. These cells account for.

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Deenen GJ, Van Balen I, Opstelten D: In rat B lymphocyte genesis sixty percent is lost from the bone marrow at the transition of nondividing pre-B cell to sIgM + B lymphocyte, the stage of Ig light chain gene expression. Eur J Immunol ;

The nuceli is ejected after the cell is formed. This affects not the life span, but the ability to make energy. The life span of a red blood cell is days.

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